Showing posts with label risk. Show all posts
Showing posts with label risk. Show all posts

Friday, March 20, 2015

Obesity What are the risk factors


Lifestyle very early influence the risk of obesity.

Several factors have been identified: sleep time, time spent watching TV, standard growth curve, fast fat grain ...

They are identified in the first years of life.


Childhood obesity and the environment: the link is here
The environment is very early and plays a decisive role in the development of childhood obesity. The early identification of factors that promote excess weight makes a suitable and effective prevention.

A study conducted from 8000 children aged 7 years and followed from birth, allowed to list many risk factors for obesity, identifiable during infancy.

Of course, a high birth weight and parental obesity increase the risk.
A genetic mechanism, family environmental or dietary habits can be the cause.

But other environmental indices were also recorded as the duration of sleep: sleep and less than eleven per day at the age of three years favors the appearance of excess weight.

Hormonal factors, late food intake or lack of physical activity can play an important role.

Time spent watching TV is also implicated, even among the very young. Thus, from the age of three years, a child who spends more than eight hours a week in front of the screen has a high risk of becoming obese and 7 years.

Other risk factors for obesity
Continuing finer analysis, the authors identified other risk factors:

an early difference between 8 and 18 months, compared with the growth curve;

a rapid gain of fat tissue before 4 years;

a high weight gain in the first year of life.
Two other factors can not be ignored: the protective effect of breastfeeding and diet appropriate to the age of three years.

Conclude to better prevent obesity in children?
In conclusion, there are many signs that must be identified early childhood to adopt preventive measures, all the more effective they will be in place early, before the extra pounds will be installed.

Its worth to be vigilant (e) and talk to his doctor or pediatrician at the first warning signs!

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Monday, March 16, 2015

Gut Flora Risk and Repair

….All 190 posts here….
The two most important contributors to health are diet and gut flora.  All of the other contributors, such as exercise, genetics, environmental toxins, hygiene, etc. are of minor importance.  A healthy diet, such as The Anti-Inflammatory Diet that I recommend on this blog, is simple and relatively easy to follow after weaning from the Standard American Diet.  One version of the healthy diet is just eating meat, fish, eggs, dairy and plenty of vegetables, but avoiding vegetable oils and grains.  Most people will be healthy with that general diet, but if and only if, they also have a healthy gut flora that is adapted to the food they eat.

Most people make themselves sick by not matching their gut bacteria to what they eat, so let me repeat the main point of this article:

You will get sick if the bacteria in your colon can’t digest your food.
And sick means allergies, autoimmunity, cancer, etc.
Read and Heed or Dead

What Killed American Gut Flora?
There are hundreds of different species of bacteria growing on partially digested food (soluble fiber) in your colon.  Americans are sick, not because they are too poor to buy food, but because they have the worst, i.e. least diverse, gut flora in the world.

Do:  We pick up, recruit, eat new bacteria and repair our gut flora by:
  • touching surfaces, people, pets, etc. and putting our fingers near our mouths,
  • eating live fermented food, or semi-clean vegetables,
  • not cooking/killing/sanitizing all of the bacteria around us,
  • eating probiotics and transferring some of their genes to our gut flora.

Don’t:  We wipe out or reduce the diversity of our gut flora by:
  • using inappropriate hygiene that kills the bacteria we need for health,
  • taking antibiotics that kill gut flora and compromise our immune system,
  • trying to eat a wide variety of foods, which is counterproductive and only permits a few varieties of bacteria to survive.

Hygiene Kills Beneficial Bacteria
Nothing comes from nothing…  For bacteria to come out, bacteria must go in.  You have to eat bacteria to extrude them by the pound.  Each day a single bacterium growing and dividing in your gut once per hour will produce a million daughter bacteria (24 doublings, estimate that doubling two, ten times is about a thousand, and 1000X1000= million.)  So if you mixed a milligram (about the size of the period at the end of this sentence) of gut bacteria with ample food, you would have a kilogram (pounds) of bacteria by the end of the day.  Similarly, it takes about a day for a single bacterium applied to a petri dish of nutrient agar to produce a colony weighing about 10 milligrams.  The point here, is that a single bacterium that makes it through the acid bath of the stomach can be a major player in your colon in a couple of days.  This is a very good thing.  We want to kiss babies, because babies systematically vacuum up bacteria from the darkest  of corners and with shameless generosity present them in an irresistible pucker.  We need those bacteria, and so do the babies.  Hygiene, e.g. antibacterial hand soap, bleaching surfaces or closing toilet lids isolates people from potential sources of beneficial gut bacteria. 

Traditional Food is Fermented (with Live Bacteria)
Shockey
In most cultures, extra food is mixed with something like salt or spices to kill local problem microbes and then bacteria are permitted to grow.  The result is fermentation of the sugars available in the food with production of organic acids, e.g. vinegar, that stop the growth of other bacteria that might grow on protein and cause objectionable flavors.  Homemade fermented veggies contain a wide variety of happenstantial bacteria that can adapt to productive gut growth.

Cooking Kills
We cook to dissolve and soften foods.  Meat can be eaten whole and our stomach enzymes will easily digest the protein and fat to provide all of our nutritional needs.  The only plant material that can be digested by our enzymes is starch.  The rest of the plant requires cooking to make the protein available and the remaining carbohydrates, soluble fiber, require digestion by hundreds of different enzymes produced only by microorganisms.  Cooking will release soluble fiber to feed gut flora, but it also kills bacteria, so some raw foods must be eaten to make sure that the gut is always supplied with fresh bacterial recruits.  Cooked or pasteurized foods do not contain live bacteria and are not useful as sources to repair gut flora.

Probiotics are not Gut Flora
Commercial probiotics are made from bacteria used in dairy products (dairy probiotics) or bacteria used to make enzymes in other products, such as laundry detergents.  
These bacteria can be repackaged and sold as probiotics, because they have already been tested for toxicity.  These bacteria don’t normally grow in the gut and if you swallow them, they just pass through.  These “probiotics” can temporarily provide some of the functions of gut flora, because they are bacteria, but they don’t grow in the gut.

Gut Flora are Bacteria Created in the Gut
Gut bacteria produce chemical signals that coordinate the metabolism of food by hundreds of different species of bacteria.  We call these chemical signals vitamins, because humans extract the vitamins from the bacterial biofilms that always line the gut, so humans don’t need to produce their own vitamins.  Gut flora can produce all of the vitamins that we need, so it is not surprising that multivitamins do not provide any health benefit and concentrated vitamins my be harmful by disrupting normal metabolism of gut flora.  Biofilms also promote the exchange of genes between different species of bacteria, so the concept of species does not actually apply to gut flora, where new species are rapidly being created.  A common example of this process is the curing of lactose intolerance by simply eating small amounts of live yogurt for a couple of weeks.  The cure results from the transfer of a gene that produces an enzyme to digest lactose from the yogurt probiotic bacteria to the regular gut bacteria.  The new species, a natural GMO, continues to grow in the gut, digest lactose, and cure lactose intolerance.  The yogurt probiotics just get flushed away and that is why dairy probiotics must be eaten continuously to provide some of the benefits of healthy gut flora.

Antibiotics Kill Gut Flora, Compromise the Immune System and Cause Disease
Antibiotics are a huge benefit in curing and avoiding infectious disease.  Unfortunately, antibiotics can cause lasting damage by killing beneficial species of bacteria of the gut flora.  Loss of essential bacteria is commonly seen as food intolerances (true food allergies are rare) or constipation.  Since gut flora are needed for development of both the aggressive and suppressive parts of the immune system, which occurs in the lining of the gut, then antibiotics slowly lead to loss of function of the immune system that leads to autoimmunity or allergies.  Probiotics typically administered following antibiotic treatments do not repair the gut flora and leave the immune system damaged and prone to autoimmune diseases and allergies.

Variety in Foods Leads to Loss of Diversity in Gut Flora
It may be more entertaining to eat a new cuisine at each meal, but it confuses your gut flora.  Your gut is a river that endlessly moves food from mouth portal to pottie.  Bacteria divide and eddies cast some of the bacteria back to mix with food upstream before inevitably moving with the masses down and out.  Bacteria that don’t multiply as quickly as others eventually become extinct.  Bacteria that grow well on broccoli may wither with onions.  If you continue to eat some broccoli and some onions, then your gut flora will adapt, but if the type of polysaccharides, the soluble fiber, changes continuously, then you will end up with the stunted gut flora of Americans.  Diversity of gut flora is reduced by too much variety in food.

Matching Food to Gut Flora Takes Time
All of the gut problems that people complain about, gas, bloating, diarrhea, constipation, food intolerances/allergies (except gluten and a couple of others), etc. are due to a mismatch between food and the digestive enzymes of gut flora.  Modern food processing retains protein, fat and starch and removes the polysaccharides/soluble fiber that reaches the colon, feeds gut bacteria and produces short chain fatty acids (acetic acid, butyric acid, propionic acid) that feed the colon and reduce inflammation.  It takes time for gut bacteria to adapt to new soluble fiber in new foods by recruiting or creating new bacteria, and this is only possible, if inappropriate hygiene is avoided or if homemade fermented foods are eaten.
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Friday, March 6, 2015

Red Meat Breast Cancer Dietary Protein Sources in Early Adulthood and Breast Cancer Incidence 22 Risk Increase for Red Meat Eaters Substituting Poultry Normalizes Risk

Red (meat) breast cancer alert!
Its not the first study and I am pretty sure its not going to be the last study to link red meat and cancer, but in view of the fact that I am pretty sure that the results Maryam S Farvid and colleagues present in their latest paper in the British Journal of Medicine are going to be all over the place this week, I feel that its worth to give you an unbiased overview of the results before you are confronted with the sensational press release celebrating the newest "Harvard science" - a source people trust, one that "propagates the truth" and one that is (ab-)used by press release writers to generate the impression that each and every word they write is true.

Well the truth is that we are dealing with yet another prospective epidemiological study which does not have the power to reveal causal links between parameter (a), in this case the dietary protein sources in early adulthood and parameter (b), which is the incidence of breast cancer.
Learn more about meat at the SuppVersity

Meat-Love: You May Eat Pork, too!

You Eat What You Feed!

Meat & Prostate Cancer?

Meat - Is cooking the problem

Meat Packaging = Problem?

Grass-Fed Pork? Is it Worth it?
The average ignoramus will still read the headlines as "red meat" causes cancer and think of poultry, fish, eggs, legumes, and nuts as "the cure". In contrast to the red meat intake which was associated with a 22% risk increase in the 2830 documented cases of breast cancer the scientists had been collecting and following for 20 years, the a higher intake of poultry, fish, eggs, legumes, and nuts was
not just unrelated to breast cancer, in postmenopausal women, a high poultry intake was even associated with a -27% reduced breast cancer risk.
Energy intake and cancer risk expressed relative to lowest intake quintile for red meat (Farvid. 2014)
The latter observation gives rise to one of the (imho) hilarious substitute this for that equations, where the "estimating the effects of exchanging different protein sources, substituting one serving/day of legumes for one serving/day of red meat was associated with a 15% lower risk of breast cancer among all women (0.85, 0.73 to 0.98) and a 19% lower risk among premenopausal women (0.81, 0.66 to 0.99). Substituting poultry for red meat was even associated with 17% and 24% lower breast cancer risk in all and postmenopausal women.

Unlike the fooled readers of the press release, the researchers are obviously aware of the weaknesses of the study, in the discussion of the results, Farvid et al. point out that "potential limitations need to be considered":
  • participants were predominantly white, educated US adults, they cannot determine whether our findings are generalizable to other race or ethnic groups
  • dietary intake was assessed by food frequency questionnaires, some degree of measurement error is inevitably present, and thus to reduce measurement error they used the cumulative average of
    multiple measurements in a sensitivity analysis
  • residual confounders are always of concern in any observational studies; although they adjusted for a wide range of potential confounders for breast cancer, they still could not rule out the possibility that other unmeasured or inadequately measured factors have confounded the true association
  • they only estimated the effects of substitution of legumes, poultry, and other protein sources for red meat on risk of breast cancer, when trials on dietary modification would be ideal to support these substitutions
In addition, the scientists made multiple comparisons (different food groups and nutrients, premenopausal and postmenopausal subgroups, and subtype of tumors) in this analysis, and can thus not exclude the possibility of type I errors. But (sarcasm) this is not so much of concern, "the central finding of an association with red meat was [after all] a prior hypothesis." (Farvid. 2014) - In other words: What do you want people, weve just made sure we confirm our hypothesis.
Page from the original questionnaire | What? You dont know the margarine brand you have been using, when you were in highschool? Must be Alzeimers due to all the red meat!
So, here you have it: All youve got to do is to consume tons of poultry. Thats probably even going to cure breast cancer... right?  I am obviously sarcastic, but with data thats based on a semi-quantitative food frequency questionnaire with approximately 130 items in 1991, 1995, 1999, 2003, and 2007 about usual dietary intake and alcohol consumption during the past year - the same that was already used in the Nurses Health study, by the way (download it here), the results are about as reliable as your ability to tell me which brand of margarine your family has been using, when you were in high school (I am not kidding, this was one of the questions).

So instead of panicking, it would be wise to file this study next to the other "pizza salami is meat and meat is bad" studies Ive written about in the past (read more) - and remember: The "Harvard" label may stand for excellent research, but it also stands for the support of lobbyists and interests groups.
Reference:
  • Farvid, et al. "Dietary protein sources in early adulthood and breast cancer incidence: prospective cohort study." BMJ 2014;348:g3437 doi: 10.1136/bmj.g3437
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